AB004: Resuscitation of axon regenerative potential in mature retinal ganglion cells
Theme 1: Regenerative Medicine

AB004: Resuscitation of axon regenerative potential in mature retinal ganglion cells

Leung Kai Shun Christopher

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, The Chinese University of Hong Kong, Hong Kong SAR, China


Abstract: Axon regeneration capacity declines in mature retinal ganglion cells (RGCs). While a number of transcription factors and signaling molecules have been implicated to the loss of regenerative potential of RGC axon, their upstream regulators are unclear. We investigated the association between developmental decline of RGC regenerative potential and age-related changes in microRNA (miRNA) expression and showed that loss of axon regenerative potential can be partially restored by upregulating miR-19a in RGCs in vitro and in vivo. Regulating miRNA expression represents a new potential therapeutic approach to resuscitate age-related loss of axon growth ability.

Keywords: microRNA (miRNA); retinal ganglion cell (RGCs); axon regeneration


Cite this abstract as: Christopher LK. Resuscitation of axon regenerative potential in mature retinal ganglion cells. Ann Eye Sci 2017;2:AB004. doi: 10.21037/aes.2017.AB004

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