AB004. Regulation of retinal angiogenesis and vascular permeability by bone morphogenetic protein signaling
Retina and Posterior Segment

AB004. Regulation of retinal angiogenesis and vascular permeability by bone morphogenetic protein signaling

Bruno Larrivée

Department of Ophthalmology, Hôpital Maisonneuve-Rosement Research Centre, Université de Montréal, Montreal, Canada


Abstract: The bone morphogenetic protein (BMP) family of proteins has a multitude of roles throughout the body. It plays important roles in development and in the adult vascular endothelium, by modulating the angiogenic response. The endothelial-specific receptor BMP receptor Alk1 is of particular importance in the proper remodeling of the vasculature and its ligand BMP9 has been shown to be a potent inhibitor of neovascularization. Dysregulated BMP signaling has been linked to multiple vascular diseases and can lead to the abnormal angiogenesis. We therefore investigated the role of BMP9/Alk1 signaling in retinal angiogenesis, and its therapeutic implications for vascular pathologies of the eye.

Keywords: Retinal angiogenesis; bone morphogenetic protein (BMP); vascular permeability


doi: 10.21037/aes.2018.AB004
Cite this abstract as: Larrivée B. Regulation of retinal angiogenesis and vascular permeability by bone morphogenetic protein signaling. Ann Eye Sci 2018;3:AB004.