Additional clinical insights into subtype-specific orbital lymphomas

Anna M. Stagner, Lawrence R. Zukerberg


Ocular adnexal (OA) lymphoproliferative disorders are a heterogeneous group of diseases that for many years were lumped together by clinical ophthalmologists for prognostication purposes (1). The majority are extranodal non-Hodgkin’s small B cell lymphomas, first largely characterized before current classification systems or diagnostic tools existed (2). The term “ocular adnexa” refers to the structures surrounding the eye itself including the orbital soft tissues, eyelids, conjunctiva, lacrimal production and drainage system and the extraocular muscles; each of these sites can be afflicted with disease.