TY - JOUR AU - Park, Choul Yong AU - Chuck, Roy S. PY - 2019 TI - Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis JF - Annals of Eye Science; Vol 4 (February 2019): Annals of Eye Science Y2 - 2019 KW - N2 - In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies ( in vivo and in vitro ) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians. UR - https://aes.amegroups.org/article/view/4692